NHP(monkey) Disease Models

Non-human primate (NHP) models are essential tools in basic research, drug discovery, and development. Their close genetic, anatomical, and physiological similarities to humans make them invaluable for studying human diseases and developing new treatments. NHP models provide critical insights that bridge the gap between basic research and clinical applications, ensuring that findings can be translated effectively into medical advancements. Despite the progress in in vitro methods, NHP models remain irreplaceable for human translational research.

 

Prisys's Approach and Expertise

 

Prisys excels in developing and utilizing NHP models, particularly induced and surgical models. Our expertise spans multiple research areas such as immunology , cardiovascular , respiratory , neurological , and metabolic diseases . We employ physical methods (e.g., mechanical, surgical, gene editing) to create phenotypes that closely resemble human conditions. For instance, ischemic events can be surgically induced to study stroke survival or cardiac reperfusion post-heart attack. 

At Prisys, we recognize the vital role that NHP models play in biomedical research. With extensive experience and expertise, we offer a comprehensive range of NHP models tailored to meet the diverse needs of our global clients. Our scientists are dedicated to assisting you in selecting the most appropriate model for your research, ensuring high fidelity to human biology for accurate and reproducible results.

Prisys is committed to advancing scientific research by providing top-quality NHP models and expertise. Please click on the links below to access our signature NHP models or contact our scientists to customize your own models.

Customized Model Development

In addition to our existing models, we continuously improve our technology to develop new animal models that meet the evolving needs of our clients. In our history about 30% novel NHP models were generated, refined, and stabilized through a special mechanism call "Co-develop", where joint efforts and combined expertise from Prisys and collaborators were invested to develop NHP models with mutual interests. The development, aiming at offering a better tailored solution to assess drug pharmacology, was routinely initiated with a small pilot proof-of-concept study then followed by a bigger therapeutic project. For more detailed information or to consult with our scientists, please contact us directly.

Goals of In Vivo Efficacy Models

 

Determining whether a compound can produce the desired physiological response.

Comparing the impact of various doses of the same compound.

Evaluating the efficacy of different compounds relative to each other.

 

Efficacy in in vivo models is typically measured by the dose provided and the percentage effect relative to the maximal effect achievable. The most commonly reported value is the ED50, the dose at which 50% of the maximum effect is observed. These values are crucial for ranking compounds within a specific in vivo model.

Prisys is committed to advancing scientific research by providing top-quality NHP models and expertise. Please click on the link below to access our off-the-shelf models or contact our scientists to customize your own model. For more detailed information on our models or to consult with our scientists, please explore our library of models or contact us directly.

Contact Us for More Info

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