CT-lung volume module
Research Platform for Respirology Disease Research
The Respirology disease area focuses on the study and treatment of diseases affecting the respiratory system. This field encompasses a wide range of conditions that impact the lungs and airways, including both acute and chronic diseases. Research in respirology aims to understand the pathophysiology of respiratory disorders, improve diagnostic techniques, and develop effective treatments and preventive measures. Utilizing advanced animal models, clinical trials, and cutting-edge technologies, researchers explore the mechanisms of lung diseases and evaluate new therapeutic approaches. A comprehensive approach is essential for improving patient care, enhancing treatment outcomes, and advancing respiratory health.
Why Use NHP for Respirology Disease Research Modeling
Using non-human primates (NHP) in respirology disease research is highly advantageous due to their close physiological and immunological resemblance to humans. This similarity ensures that data from NHP models are highly translatable, enhancing the accuracy of preclinical findings and supporting the development of effective treatments for respiratory diseases such as asthma, COPD, and pulmonary fibrosis. NHPs' complex lung anatomy and immune system allow for detailed and reliable study of disease mechanisms and therapeutic interventions, making them indispensable for advancing human respiratory health.
Physiological Similarity
NHPs have lung structures and respiratory functions closely mirroring those of humans, making them highly relevant for studying human respiratory diseases.
Immunological Resemblance
The immune responses of NHPs are remarkably similar to those in humans, enabling accurate modeling of respiratory disease mechanisms and immune interactions.
Translatability
Data obtained from NHP models are highly translatable to human conditions, enhancing the predictive value of preclinical research and the development of effective treatments for diseases such as asthma, COPD, and pulmonary fibrosis.
Complex Disease Modeling
NHPs' sophisticated lung anatomy and immune system allow for the detailed study of complex respiratory disease mechanisms and therapeutic interventions, providing robust insights into disease progression and treatment efficacy.
Reliable Results
The use of NHPs ensures robust and reliable preclinical findings, which are critical for advancing human health and accelerating the development of new respiratory disease therapies.
Superior Platform for Respirology Research at Prisys
The Respiratory Technology Platform at Prisys Biotech is designed to address various respiratory conditions through innovative research models and delivery technologies. This platform supports the development of new treatments by simulating human respiratory diseases in NHP models , ensuring high translational value:
Lung & Airway Delivery
Intratracheal aerosol, lung distillation, and airway sampling techniques are used to administer drugs directly to the respiratory system.
Lung Distillation
Lung distillation techniques allow for the administration of drugs in a liquid form directly to the lung tissue, enhancing absorption and efficacy.
Airway Sampling
Airway sampling techniques are used to collect samples from the respiratory tract, providing valuable data for respiratory research and drug development.
Respirology Disease Models
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Chronic Obstructive Pulmonary Disease (COPD) : Chronic bronchitis Emphysema |
Asthma: Non-allergic asthma Exercise-induced asthma |
Interstitial Lung Diseases (ILD): Idiopathic pulmonary fibrosis (IPF) Sarcoidosis Hypersensitivity pneumonitis |
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Infectious Respiratory Diseases: Pneumonia (bacterial, viral, fungal) Tuberculosis (TB) Influenza COVID-19 |
Pulmonary Vascular Diseases: Pulmonary hypertension Pulmonary embolism |
Lung Cancer: Non-small cell lung cancer (NSCLC) Small cell lung cancer (SCLC) Mesothelioma |
FAQ
What makes non-human primates (NHP) ideal for respirology disease research at Prisys?
Physiological and Immunological Similarity: NHPs have respiratory systems and immune responses that closely resemble those of humans. This similarity ensures that research findings are highly relevant and translatable to human conditions, enhancing the accuracy of preclinical studies.
How does Prisys enhance the translational value of respirology research?
Highly Translatable Data: Using NHP models at Prisys generates data that closely mirrors human responses, thus improving the predictive value of preclinical research. This supports the development of effective treatments for respiratory diseases like asthma, COPD, and pulmonary fibrosis.
What advanced respiratory disease models are used at Prisys?
Comprehensive Disease Models: Prisys employs models such as atopic diseases, inflammatory pneumonia, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD) in cynomolgus monkeys. These models replicate key aspects of human respiratory diseases, allowing detailed study of disease mechanisms and therapeutic interventions.
How do Prisys's research platforms and techniques support respiratory disease research?
Innovative Research Platforms: Prisys's Respiratory Technology Platform includes advanced methodologies like intratracheal aerosol delivery, lung distillation, and airway sampling techniques. These technologies enhance drug delivery and data collection, ensuring high translational value and supporting the development of new treatments for respiratory diseases.