Psoriasis Model

Name: Psoriasis Model Study - Monkey Psoriasis Model
Brand: Prisys
SKU: 199951531

Explore the intricacies of psoriasis, an immune-mediated genetic disease, including its causes, symptoms, and the various types of this chronic skin condition. Discover how Prisys utilizes a non-human primate (NHP) model to study psoriasis, focusing on clinical endpoints like PASI scoring, immunotyping, and histopathology. Learn how this model contributes to understanding the Th17 immune response and the development of potential new treatments. Contact us to delve deeper into our research findings and explore potential collaborations.

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Product Introduction

Psoriasis, is an immune-mediated, genetic disease manifesting in the skin or joints or both. It is long-lasting, non-contagious autoimmune disease characterized by patches of abnormal skin.

Psoriasis

Disease symptoms: plaque, guttate, inverse, pustular, and erythrodermic

Causes: Psoriasis is generally thought to be a genetic disease that is triggered by environmental factors. Psoriasis has been associated with HLA-Cw6 allele; generalised pustular psoriasis has been linked to CARD14 mutation; CDKAL1 has been associated with psoriasis.

Mild trauma such as scratches, piercing, tattoos, sunburn, and chemical irritants are considered as trigger factors.

Central mechanisms of the disease involves the cross-talk between innate and adaptive immunity and the central role of TNFα; the IL23/Th17 axis, and the effect of immune reactions on other cells in the skin.

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Disease symptoms:

These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small localized patches to complete body coverage. Injury to the skin can trigger psoriatic skin changes at that spot, which is known as the Koebner phenomenon.

The five main types of psoriasis are plaque, guttate, inverse, pustular, and erythrodermic. Plaque psoriasis, also known as psoriasis vulgaris, makes up about 90% of cases. It typically presents as red patches with white scales on top. Areas of the body most affected are the back of the forearms, shins, navel area, and scalp. Guttate psoriasis has drop-shaped lesions. Pustular psoriasis presents as small, noninfectious, pus-filled blisters. Inverse psoriasis forms red patches in skin folds. Erythrodermic psoriasis occurs when the rash becomes very widespread and can develop from any of the other types. Fingernails and toenails are affected in most people with psoriasis at some point in time. This may include pits in the nails or changes in nail color.