Immunosuppression Model

Immunosuppression Model

Understand immunosuppression and its therapeutic applications in managing transplants and autoimmune diseases. Learn about Prisys' cynomolgus monkey model for evaluating the effects of interventional compounds on the human immune system, particularly in the context of psoriasis. Discover the advantages of using non-human primate models for pre-clinical development of new biological treatments.
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Product Introduction

Immunosuppression, a reduction of the activation or efficacy of the immune system. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions. In Prisys, we've established immunosuppression in cynomolgus monkeys.

 

Therapeutic Immunosuppression: Managing Transplants and Autoimmune Diseases

 

In general, deliberately induced immunosuppression is performed to prevent the body from rejecting an organ transplant. Additionally, it is used for treating graft-versus-host disease after a bone marrow transplant, or for the treatment of auto-immune diseases  such as systemic lupus erythematosus, rheumatoid arthritis , Sjögren's syndrome, or Crohn's disease . This is typically done using medications, but may involve surgery (splenectomy), plasmapheresis, or radiation.

Advantages of NHP Immunosuppression model

 

Due to the high degree of similarity exists between the immune systems of human and non-human primate species, monkey models are of utmost value in evaluation the effects of interventional compounds for human immune system.
The Immunosuppression model in cynomolgus monkey is a low invasive and non-terminal model induced by  topical application.
Monkey Immunosuppression model is useful in pre-clinical development of new morbidity biologicals.

 

 
 
 

 

Immunosuppression regimen for cell/organ transplantation:

 

Lineage specific cell depletion protocol (upon request):

Methylprednisolone

Thymoglobuline (ATG)

Prednisone

Tacrolimus

Mycophenolate mofetil

CD8+ T Cell Immunosuppression

 

 

 

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T Cell Immunosuppression

 CD4+ T Cell Immunosuppression

 

B Cell Immunosuppression

NK Cell Immunosuppression

 

 

 

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