Multiple Sclerosis Nonhuman Primates Disease Model

Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model of MS. Prisys Biotechnologies offers an NHP model of EAE induced by immunogenic peptides. The standard study duration is 8 weeks, during which the clinical endpoints include brain MRI and CT, neurologic deficit scoring, histopathology, and other assessments.

This NHP model has several features that make it useful for MS research. The NHPs have a human-like brain structure and develop similar neurologic deficit symptoms to human MS. Brain lesion analysis can be performed, providing insights into the pathophysiology of the disease. Additionally, potential complications of MS, such as cognitive deficits, can also be assessed.

Overall, the NHP model of EAE induced by immunogenic peptides is a valuable tool for studying the pathogenesis of MS and for testing potential therapeutics.

Furthermore, the Prisys Biotechnologies' NHP model of EAE also features the induction of neurologic deficit symptoms similar to those seen in human MS patients, including limb weakness, paralysis, and gait abnormalities. Brain lesion analysis is performed to assess the extent and distribution of demyelination and inflammation in the brain and spinal cord. Complications such as seizures and infections are monitored and managed appropriately to ensure the safety of the animals. The use of NHPs in EAE research provides a valuable tool for understanding the complex immunological and neurological processes involved in MS pathogenesis and for evaluating the efficacy and safety of potential therapies.

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