Clinical Imaging
The Application of in vivo Imaging in NHP Studies
Prisys Biotech offers an advanced Clinical Imaging Platform (PRISYS Translational Research Center ) designed to enhance drug development, particularly from preclinical to Phase II clinical stages. Our platform provides clinical equivalent imaging results from human imaging devices and analytical methodologies, ensuring smooth translation of preclinical data.
By using devices such as MRI, CT, and DSA, we are able to deliver high-resolution, real-time imaging of non-human primates (NHPs), allowing for the accurate assessment of disease progression, drug distribution, and therapeutic efficacy. Our platform is tailored for a variety of research areas, including CNS, cardiovascular, and respiratory diseases. These technologies enable non-invasive monitoring, reducing the need for terminal procedures, and enhancing the overall welfare of the animals involved.
Clinical Imaging Key Features
Prisys In vivo Imaging Platform:
- Heavy equipment: MR, CT, PET-CT, DSA (x-ray), DEXA
- Diagnostic devices: doppler ultrasound, colonoscope, laparoscope, bronchoscope
Advanced Analytical and Diagnostic Capabilities:
- Team of clinical radiologists with 20+ years of experiences from clinics, enabling direct disease justification, lesion quantification, and diagnostic reporting after imaging scans
- 10+ years of endeavor in fitting human imaging scan & sequencing to NHP, including device refinement, sequencing customization, and countless validation trails.
General Applications:
- Drug Efficacy and Safety: enables precise assessment of drug efficacy and safety in various disease models, providing unique disease endpoints with comparative readouts for drug effeteness in different disease stages.
- Disease Progression Monitoring: allows continuous monitoring of disease progression and therapeutic effects, enhancing understanding of chronic disease mechanisms and treatment responses without the necessity of animal euthanasia.
High Predictive Value:
- Target/Biomarker discovery and validation: supporting the identification and validation of new drug target or biomarkers by means of radio-label-based tracing.
- High Predictive Value: Ensures high predictive value in translational research, reducing later clinical phase risks and supporting informed decision-making in drug development.
MRI (Magnetic Resonance Imaging)
System: United Imaging 1.5T Superconducting MRI System, u580
Special Configurations: Infant Coil-24: A 24-channel infant head-neck combined coil designed specifically for non-human primates, ensuring high-quality imaging.
Advanced Scanning Applications:
- MATRIX, 2D/3D GETI, Brain PERFUSION, Advanced DTI, CSI 3D MRS, SWI, Maps
Advanced Post-Processing Software:
- ADVIP-Brain Perfusion (Mismatch), ADVIP-United Neuro (DTI&DTT), ADVIP-MRS(CSI)
CT (Computed Tomography)
System: United Imaging 40-Slice Spiral CT, u528
Key Specifications:
- Detector Thickness: 0.55mm
- Gantry Aperture: 70cm
- Fastest Scan Speed: 0.75 seconds per rotation
Advanced Applications:
- Lung Nodule Advanced Analysis: Quantitative analysis and follow-up comparisons for space-occupying lesions such as lung cancer
- Lung Parenchyma Advanced Analysis: Quantitative measurement of emphysema (volume)
- Cranial Perfusion Analysis: Quantitative evaluation of brain infarctions and tumors
DSA (Digital Subtraction Angiography)
System: Ziehm Vision RFD Mobile C-Arm Digital Subtraction Angiography System
Key Features:
Equipped with high-pressure injectors, shadowless lamps, ceiling-mounted towers, monitors, and anesthesia machines.
Supports interventional surgeries for cardiovascular, neurological, and peripheral conditions.
Facilitates image-guided surgeries in orthopedics and general surgery.
Operating Room (OR)
System: Equipped with laparoscopes, ultrasonic scalpels, electrosurgical units, anesthesia machines, shadowless lamps, ceiling-mounted supply units, and patient monitors.
Key Specifications:
Laparoscopes, Ultrasonic Scalpels, Electrosurgical Units, Anesthesia Machines, Shadowless Lamps, Ceiling-Mounted Supply Units.
Advanced Applications:
- Minimally Invasive Surgery: Enhanced visualization and precision for laparoscopic procedures
- Tissue Dissection: Efficient and controlled cutting with ultrasonic and electrosurgical tools
Applications in Disease Areas
Gastrointestinal System : MRI and CT for abdominal imaging, dynamic contrast enhancement, and organ-specific scans.
Musculoskeletal System : MRI and CT for joint and spine imaging, including quantitative cartilage assessment.
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