MRI-Guided Drug Delivery For CNS Research
ClearPoint Navigation For CNS Research
Prisys Biotechnologies has installed a leading image-guided drug delivery platform, the first of its kind in China, to optimize the delivery of investigational gene, cell, and other therapies directly to the brain parenchyma for pre-clinical applications. With Prisys' in-house MR imaging system, the new technology combines specialized MRI-compatible hardware and software to plan surgical trajectories and guide the infusion cannula to target. Targeting and dosing can be optimized throughout this minimally invasive procedure to improve safety and efficacy.
The Prisys surgical approach offers several advantages over conventional methods:
Sub-millimetric
The Intraprocedural MRI-guided drug delivery system provides sub-millimetric accuracy and precision.
Target
A safe, minimally invasive procedure performed by a skilled team enables reliable access to multiple deep anatomical targets
Micro-infusion
Convection Enhanced Delivery (CED) improves micro-infusion distribution to the target structure.
Translation
Translational continuity from pre-clinical studies through clinical trials.
Optimize Visualization And Surgical Trajectory Planning Of CNS Injections Under MRI
The ClearPoint® System revolutionizes the field of neurosurgery by providing intraprocedural MRI guidance, resulting in unparalleled accuracy and precision in the delivery of therapeutics to the brain.
Read more details at:
https://www.clearpointneuro.com/biologics-drug-delivery/neuro-navigation-system-software/
The ClearPoint System is translatable from large animal models to clinical trials. An additional frame provides additional flexibility to access the most challenging entry points.
Read more details at:
https://www.clearpointneuro.com/clearpoint-pre-clinical-orchestra-frame/
An MRI-compatible drug delivery cannula is optimized for precision drug delivery procedures while minimizing dead volume.
Check more details at:
https://www.clearpointneuro.com/biologics-drug-delivery/smartflow-cannula/
The ClearPoint System is a safe, efficient, and reliable way to deliver novel therapeutics to specific structures in the brain with the aid of integrated MR-brain-mapping. Cumulated case-studies in both human patients and large experimental animals, and rich clinical evidence have proved its effectiveness therefore becoming the ultimate solution for translational R&Ds of relevant therapeutics, such as Small Molecules, Biologics, Cell and Gene Therapies, Nanoparticles, and Nucleic Acid-based Therapies. Major advantages include:
01
Enhancing delivery efficiency and efficacy
The ClearPoint System allows precise confirmation of the infusion location, while monitoring dosing into the parenchyma.
02
Reducing variability and improving reporducibility
The ClearPoint System standardizes the delivery protocol and eliminates human error or bias.
03
Minimizing tissue damage and inflammation
The ClearPoint System uses thin and flexible micro-needles that can penetrate the blood-brain barrier without causing significant bleeding or trauma.
04
Facilitating translational research
The ClearPoint System enables the use of larger animal models that are more representative of human anatomy and physiology, while providing high-quality data that can support regulatory approvals and clinical trials.
Using the intraprocedural MRI-guided technology, Prisys strives to provide a unique experience and an advanced pre-clinical solution for your drug R&D work.With the ClearPoint System, you can perform various procedures, such as:
- Gene Therapy
- Cell Therapy
- Biopsies
- Innovative Devices
How Does The ClearPoint System Putperform Other Methods
The ClearPoint System is a state-of-the-art neuro navigation system that uses real-time MRI guidance to safely deliver therapeutics to the brain with high precision. Compared to other methods or systems, the ClearPoint system offers several advantages, such as:
Precision
The ClearPoint System uses real-time MRI imaging to ensure accurate and consistent delivery of therapeutics to the desired location, avoiding any errors or deviations that could affect the outcomes.
Safety
The ClearPoint System reduces the risk of infection, bleeding, or neurological damage by using sterile disposable components and avoiding invasive surgery or large incisions.
Flexibility
The ClearPoint System can deliver various types of therapeutics, including small molecules, proteins, antibodies, nucleic acids, viruses, stem cells, or nanoparticles, to different structures deep in the brain, depending on the research goals and design.
Scalability
The ClearPoint System is compatible with large animal models, and can perform multiple injections in a single session, increasing the productivity and efficiency of pre-clinical research.
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