Prisys Biotech specializes in advanced nonhuman primate (NHP) research, leveraging cynomolgus monkey models and translational platforms to support preclinical drug development. With AAALAC full accreditation, we uphold the highest standards of animal welfare and scientific rigor, enabling global biopharmaceutical companies to generate reliable, clinically translatable data.
Why Biodistribution Studies Matter
Biodistribution studies are a cornerstone of preclinical research. They provide critical insight into the absorption, distribution, metabolism, and excretion (ADME) profile of drug candidates-particularly their localization and kinetics within target organs and tissues.
Cynomolgus monkeys, due to their close genetic, physiological, and pathological similarity to humans, serve as an unparalleled model for predicting human drug behavior. These studies are indispensable for:
- Reducing clinical trial failure rates
- Understanding mechanisms of action
- Optimizing dosing regimens
- Evaluating safety and supporting IND submissions
Prisys Biotech's Core Platforms for Biodistribution Studies
1. Advanced Imaging & Analysis
- MRI & CT: Equipped with 1.5T high-field MRI and 40-slice CT, we provide high-resolution scans with advanced post-processing (3D-ASL, perfusion analysis, fat quantification, pulmonary nodule analysis, cerebral perfusion, etc.).
- PET-CT / PET-MR / SPECT: Through collaborations with leading hospitals, Prisys offers radiolabeled tracer studies for quantitative biodistribution and metabolism evaluation. For example, planned studies include [18F]-labeled insulin PET-CT for nasal-to-brain delivery.
2. Precision Drug Delivery to Target Organs
- iMRI-Guided Drug Delivery: Asia's first intraoperative MRI-guided system enables sub-millimeter accuracy for brain-targeted delivery, combined with convection-enhanced delivery (CED). This platform has been applied in gene therapy programs (e.g., AMT-130 for Huntington's disease).
- DSA-Guided Organ Perfusion: Digital subtraction angiography ensures precise vascular targeting for cerebral and cardiovascular drug delivery.
- Nasal-to-Brain (N2B) Delivery: Optimized devices and imaging assessments support CNS drug delivery strategies.
- Intrathecal (IT) Administration: Enables evaluation of direct CNS effects, including EEG-based assessments.
3. Comprehensive Bio-Sample Collection & Assays
- Sampling: Serum, plasma, CSF, liver biopsies, renal tissue, retina, urine, feces, and mucosal samples.
- In-house assays: Hematology, biochemistry, coagulation, flow cytometry, cytokine profiling, IHC, HE staining, RT-qPCR.
- Collaborative testing: LC-MS, ELISpot, and advanced bioanalytical services with partner labs.
Application Examples
- Neurological disorders & gene therapy: iMRI-guided intracerebral injection for oligo, enabling real-time biodistribution mapping.
- Nasal-to-brain delivery: Evaluating novel devices for efficient CNS drug transport, validated via CT imaging and fMRI.
- PK & biodistribution studies: To assess liver biodistribution and plasma PK using biopsies and serial sampling.
- Renal disease & transplantation: Using MRA and histopathology to evaluate graft perfusion and drug effects on rejection and fibrosis.
Why Partner with Prisys Biotech
- NHP research center: 4,000 m² facility housing up to 500 cynomolgus monkeys with full surgical, imaging, and ICU capabilities.
- Experienced multidisciplinary team: Clinicians, pharmacologists, veterinarians, and translational scientists with proven expertise in large-animal research.
- Flexible collaboration models: From tailored study design to end-to-end preclinical packages bridging preclinical and clinical phases.
Conclusion
By integrating advanced imaging, precision drug delivery, and robust analytical platforms, Prisys Biotech delivers high-quality, translational biodistribution data. Our cynomolgus monkey models empower global pharmaceutical companies to accelerate drug development, improve clinical relevance, and reduce translational risks.
📩 Contact us at bd@prisysbiotech.com to explore collaboration opportunities.
