Nose-to-Brain Drug Delivery
Nose-to-Brain (N2B) Drug Delivery: Accelerating CNS Drug Development
Prisys Biotech has developed a dedicated Nose-to-Brain (N2B) drug delivery platform to support the development of central nervous system (CNS) therapeutics. This innovative solution aims to overcome the challenges of the blood-brain barrier (BBB) by enabling efficient and targeted delivery of drugs directly to the brain via the intranasal route.
Our N2B services are designed to facilitate translational studies in non-human primates (NHPs), offering researchers an effective pathway for evaluating drug delivery, distribution, and pharmacodynamics in vivo.
Core Technology and Objectives
The Prisys N2B platform leverages advanced delivery systems, and specialized NHP devices. These devices are customized with NHP-adapted nozzles to optimize dosing precision.
Key optimization parameters include:
- Nozzle geometry: Adjustable extension lengths and diameters.
- Material design: Metal nozzles coated with a thin silicone layer to minimize tissue irritation.
- Formulation compatibility: Especially suited for dry powder formulations, with tracer agents incorporated for verification.
Imaging Validation and Functional Assessment
Prisys Biotech integrates advanced clinical imaging technologies to confirm and quantify intranasal delivery outcomes:
- Dry powder formulations mixed with contrast agents allow real-time visualization of deposition.
- CT scans demonstrate concentrated linear contrast signals localized in the olfactory epithelium of the upper nasal cavity.
- MRI scans using diluted contrast agents provide consistent confirmation of deposition sites.
Quantitative Biodistribution and Pharmacodynamic Studies
To further support CNS drug development, Prisys offers extended N2B evaluation services:
- PET-CT scanning: Using radiolabeled compounds to assess quantitative biodistribution.
- Histological evaluation: Post-mortem tissue analysis with immunohistochemistry (IHC) or immunofluorescence (IHF) to determine regional distribution of delivered agents.
These integrated approaches enable clients to evaluate both delivery efficiency and pharmacological activity within the CNS.
Why Partner with Prisys Biotech?
Prisys Biotech combines:
- Specialized NHP expertise for translational CNS research.
- Validated intranasal delivery protocols optimized for reproducibility.
- Advanced imaging and functional readouts (CT, MRI, PET-CT, fMRI).
- Flexible study design options to support discovery, preclinical validation, and regulatory submissions.
This comprehensive platform ensures that our clients gain robust and clinically relevant insights into the potential of their CNS drug candidates.
Connect With Us
If you are exploring innovative intranasal drug delivery strategies for CNS therapeutics, Prisys Biotech is your trusted partner.
Contact our team today to discuss customized Nose-to-Brain (N2B) solutions for your research and development programs.
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