Biodistribution Imaging Service
Prisys Biotech offers preclinical biodistribution studies utilizing SPECT/CT imaging in the Cynomolgus monkey model. Our services are designed to provide quantitative data on the in-vivo distribution, tissue-specific uptake, and clearance of novel therapeutic compounds.
These studies support preclinical programs by providing critical data for evaluating target engagement, assessing off-target accumulation, and informing dose selection for subsequent studies.
Integrated Biodistribution Study Platform
Our service platform integrates radiolabeling, NHP model execution, and advanced imaging into a unified workflow.
1. Radiolabeling and Quality Control
- Compound Suitability: Experienced in labeling peptides, proteins, antibodies, and small molecules.
- Isotope Selection: We provide a comprehensive portfolio of isotopes for SPECT and PET applications to match the specific half-life and chemical properties of the compound being studied.
| Category | Isotope Name | Half-life | Typical Compounds for Labeling |
|---|---|---|---|
| Single Photon (SPECT) | ¹³¹I | 8 days | Peptide, protein, antibody |
| ¹²⁵I | 59.4 days | Peptide, protein, antibody | |
| ⁹⁹ᵐTc | 6.03 hours | HYNIC-modified peptide, protein, cell | |
| ¹¹¹In | 2.81 days | DOTA, DTPA modified protein | |
| Positron (PET) | ¹⁸F | 110 min | Peptide, protein, small molecule |
| ⁶⁸Ga | 68 min | DOTA, DTAPA modified protein | |
| ⁸⁹Zr | 3.27 days | Protein, antibody, cell | |
| ¹²⁴I | 4.2 days | Peptide, protein, antibody | |
| ⁶⁴Cu | 12.7 hours | Protein, antibody, cell | |
| ¹¹C | 20.3 min | Small molecule | |
| Therapeutic | ⁹⁰Y | 64.1 hours | Conjugated to specific targeted antibody |
| ¹⁷⁷Lu | 6.7 days | ||
| ¹³¹I | 8.0 days | ||
| ²²⁵Ac | 10 days |
Rigorous Quality Control (QC): Every batch of radiolabeled product undergoes a strict release protocol before administration.
2. SPECT/CT Imaging and Analysis
Our imaging facility is equipped to acquire and analyze quantitative data on radiopharmaceutical distribution.
- Imaging System: SPECT/CT system, configured with high-energy collimators for optimal resolution.
- Study Design: Longitudinal imaging at multiple time points is conducted to characterize the pharmacokinetics and retention of the compound in target tissues and clearance organs.
- Data Processing: Image reconstruction is performed with corrections for attenuation and scatter. This allows for accurate quantification of radioactivity concentration within defined regions of interest (ROIs).
Partner with Prisys for Your Preclinical Imaging Needs
We encourage direct communication with our scientific staff to discuss your specific study objectives and technical requirements. Contact us to learn more about how our biodistribution services can support your program. Contact us to discuss the specific radiolabeling requirements for your compound.
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