Inflammatory Bowel Disease Nonhuman Primates Disease Model

Inflammatory Bowel Disease (IBD) is a chronic and debilitating condition that can significantly impact a patient's quality of life. The current understanding of IBD pathophysiology suggests that it involves a dysregulated immune response to commensal bacteria in genetically susceptible individuals.

To aid in the development of effective therapies, we have developed a nonhuman primate model of IBD using dextran sulfate sodium (DSS) to induce colitis. This model allows for the study of both acute and chronic phases of the disease, with clinical endpoints such as colonoscopy, stool consistency, fecal occult blood, and body weight. Additionally, we observe colorectal ulcerative lesions in this model, which closely resemble the clinical manifestations of IBD in humans.

Our model offers the ability to investigate local treatment approaches, as well as translational diagnosis techniques for IBD.

In addition to the standard endpoints, the NHP model of DSS-induced colitis developed by Prisys Biotechnologies also enables translational studies on the disease pathogenesis and novel therapies. The model features both acute and chronic phases, allowing for the investigation of disease progression and the evaluation of the effectiveness of long-term treatment strategies. Colorectal ulcerative lesions, a hallmark of human IBD, are also observed in this model.

Moreover, local treatment can be administered in this model, providing a unique opportunity to investigate the efficacy and safety of novel drug delivery methods. The use of NHPs in this model ensures a high degree of translational relevance to human IBD, which is crucial for the development of effective treatments for this debilitating disease.

Overall, the DSS-induced colitis model developed by Prisys Biotechnologies offers a robust and clinically relevant platform for the study of IBD, with the potential to facilitate the development of new therapies and diagnostic approaches for this challenging condition.

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