NHP Neuroscience
Why NHP is critical in Neuroscience Researches
At Prisys Biotech, our NHP (Non-Human Primate) Neuroscience platform leads the way in more translatable neurological research, equipped with advanced technologies to support high-precision, impactful neuroscience R&D studies, for both therapeutic drugs (CNS/peripheral nerves) and interventional medical devices (therapeutic/diagnostic/BCIs).
The Importance of NHPs in Neuroscience Research
Non-human primates, particularly Old World monkeys like macaques, play a critical role in neuroscience research due to their close evolutionary relationship to humans. This proximity translates into significant similarities in:
Brain Structure and Function
NHP brains share a remarkable degree of anatomical and functional homology with human brains, including comparable cortical organization, complex neural circuitry, and sophisticated cognitive abilities.
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Genetic Similarity
NHPs exhibit a high degree of genetic similarity to humans, making them valuable models for studying the genetic basis of neurological disorders and evaluating the efficacy and safety of novel therapies.
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Behavioral Complexity
NHPs display a wide range of complex behaviors, including social interaction, learning, memory, and decision-making, allowing researchers to investigate the neural mechanisms underlying these processes in a model closely resembling humans.
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Disease Susceptibility
NHPs can develop several neurological conditions similar to those observed in humans, such as Parkinson's disease, Alzheimer's disease, and stroke, providing valuable models for studying disease pathogenesis and developing new treatments.
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By utilizing NHP models, researchers can gain invaluable insights into the intricate workings of the nervous system and develop innovative therapies to address a wide range of neurological disorders. Prisys Biotech's NHP Neuroscience platform leverages these advantages to drive advancements in neuroscience research and ultimately improve human health.
Advanced Capabilities
We offer a variety of transmission components
Neurosurgery Procedures and Clinical Imaging:
- Intraprocedural MRI (iMRI) procedures via ClearPoint Neuro® System
- DSA-guided CNS catheterization (e.g. MCA catheterization)
- Comprehensive MRI sequences including T1WI, T2WI, MRS, perfusion-weighed imaging etc.
- Functional MRI (fMRI) scans and automated analysis
- Hybrid PET/MRI scans with radio-isotopes
Advanced NHP Neuro-function Analysis (Behavior, Cognition, Memory etc.)
- Locomotor activity, Gait analysis: 3D behavior analysis (BehaviorAtlas®)
- Fine motor skill: Brinkman board task / Object retrieval detour task
- Memory/Attention: Color-based Delayed match to sample task
- Anhedonia, Sucrose preference test / Apathy feeding task / Attempt for apple test
Electrophysiology Signal Detection:
- Conventional EMG, Scalp EEG, subdural EEG, and SEEG capabilities
- Microscopic deep brain electrodes and micro-array implant placement
- Telemetry EEG implant for uninterrupted EEG signal recording (24/7 while un-sedated)
CNS Tissue Collection and Analysis:
- Intrathecal catheterization for long-term CSF sampling
- Confirmation of localized catheter placement via DSA before sampling
- Brain precise sampling: functional nucleus isolation, perfusion, fixation etc.
Focused Research Areas
Our team of dedicated preclinical neuroscience CRO scientists is committed to finding cures for central nervous system diseases . We continuously establishes and utilizes relevant in vivo models and assays for acute and chronic neurological diseases, aiding in the identification and testing of new compounds. Our reliable tools screen therapeutics from small molecules to biologics. We partner with you to select the most appropriate models and readouts.
Our NHP Neuroscience platform is designed to support a wide range of neurological research, with an emphasis on translational models that closely mimic human neurological conditions. Our capabilities allow for comprehensive investigation and development in the following key areas: Neurodegenerative Diseases, Neurodevelopmental Disorders, Epilepsy and Seizure Disorders, Pain and Sensory Disorders, Neuropsychiatric Disorders.
Through our comprehensive capabilities and expertise in NHP models, Prisys Biotech's Neuroscience platform is dedicated to advancing our understanding of the nervous system and developing effective treatments for a wide spectrum of neurological conditions, ultimately improving the lives of patients affected by these debilitating diseases.
Hot Tags: nhp neuroscience, research, study, monkey, gene therapy
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