Acute Hemorrhagic Shock Model NHP Model

Prisys Biotech provides advanced nonhuman primate (NHP) disease models and technology platforms across multiple therapeutic areas, including hematology research in anemia, bleeding, coagulation, and thrombosis. Among these, our acute hemorrhagic shock model in Cynomolgus monkeys (Macaca fascicularis) offers a highly translational platform to evaluate the efficacy and safety of hemoglobin-based therapeutics and anti-shock agents.

By combining precise ultrasound-guided arterial blood withdrawal with comprehensive clinical-grade physiological monitoring, this model closely replicates the pathophysiology of acute blood loss in humans. It is particularly suited for testing novel hemoglobin substitutes and resuscitation strategies.

Model Purpose and Establishment

Objective: To evaluate the pharmacological efficacy of investigational hemoglobin preparations in a primate acute hemorrhagic shock setting.

Induction Method: Acute blood loss is induced via ultrasound-guided arterial sampling.

Evaluation Goal: Following administration of the test article, its impact on physiological stability, blood oxygenation, and systemic recovery is assessed.

Animal Information

Species: Cynomolgus monkeys (Macaca fascicularis)

Physiological Monitoring

• Continuous vital sign recording
• Blood pressure
• Core body temperature
• Electrocardiogram (ECG)

Hematology & Blood Gas Analysis

• Arterial and venous blood gases
• Hematology

• Clinical Chemistry & Enzymatic Markers

• Biochemistry
• Cardiac markers

• Clinical Observation & Urinalysis

• Cage-side monitoring
• Urine testing

Advantages of the Model

• High translational value: Cynomolgus monkeys share close physiological similarity to humans, especially in cardiovascular and hematological responses.
• Precision induction: Ultrasound-guided blood withdrawal ensures controlled, reproducible modeling.
• Comprehensive monitoring: Clinical-grade instrumentation provides real-time multi-parameter safety and efficacy evaluation.
• Flexible applications: Suitable for hemoglobin substitutes, anti-shock therapeutics, and supportive care strategies.

Partner with Prisys Biotech

Prisys Biotech's acute hemorrhagic shock model integrates rigorous scientific methodology with advanced clinical monitoring to deliver reliable preclinical insights. Our expertise ensures that clients receive high-quality, reproducible data to support translational research and regulatory submissions.

Contact us today to discuss how this model can accelerate your hematology or critical care drug development program.

Hot Tags: acute hemorrhagic shock model nhp model, research, study, monkey, gene therapy, Acute Myocardial Infarction Nonhuman Primates Disease Model, vaccine PD pharmacology, NHP monkey Disease Models, preclinical, Coagulation Hemostasis Nonhuman Primates, Neuropathic Pain Nonhuman Primates