Inflammatory Bowel Disease IBD NHP Model

Name: Inflammatory Bowel Disease IBD NHP Model - China Inflammatory Bowel Disease IBD NHP Model
Brand: Prisys
SKU: 264851417

Prisys Biotech's IBD NHP Model replicates chronic inflammation and GI damage for translational research. Learn about study designs and clinical endpoints.

Send Inquiry

Product Introduction

Inflammatory Bowel Disease (IBD) encompasses chronic inflammatory conditions, including Crohn's disease and ulcerative colitis, which affect the gastrointestinal (GI) tract. These conditions result in persistent inflammation, leading to symptoms such as abdominal pain, diarrhea, rectal bleeding, and weight loss. Understanding the pathophysiology and testing potential therapeutics are critical for managing this debilitating disease.

Cause:

The etiology of IBD involves complex interactions between genetic predisposition, immune system dysregulation, and environmental factors. Models simulating inflammatory conditions within the GI tract are essential for unraveling the mechanisms driving disease progression and therapeutic response.

Advantages of Non-Human Primate (NHP) Models for IBD Research:

•Physiological and Anatomical Similarity: NHPs have a GI structure and immune system highly comparable to humans, ensuring translational relevance.

•Chronic Disease Modeling: The NHP model accurately replicates the chronic inflammation and tissue damage characteristic of human IBD.

•Behavioral and Clinical Observations: NHPs allow for detailed monitoring of clinical signs, such as altered stool consistency, body weight changes, and motor activities, in a manner reflective of human symptoms.

Advantages of NHP Models Compared to Mouse Models for Atopic Dermatitis Research:

•Enhanced Pathophysiological Insights: The immune and GI systems in NHPs align more closely with human biology than rodent models.

•Clinical Procedures: Techniques like colonoscopy and biopsy in NHPs provide direct visualization and assessment of mucosal damage, similar to human diagnostics.

•Longer Study Windows: NHP models support extended study periods, facilitating the evaluation of both acute and chronic phases of IBD.

Study design and clinical endpoints

Study design：

Prisys's IBD model is induced using a high-molecular-weight DSS solution administered orally daily over 28 days.

An acute colitis model involves high-dose DSS from Day 1 to Day 14, followed by therapeutic intervention.

Clinical endpoints:

•Colonoscopy assessments and biopsies for mucosal integrity.

•Colon length and weight measurements as indicators of inflammation severity.

•Histopathological examination of colon tissues to evaluate inflammatory and fibrotic changes.

•Intestinal MRI technology to provide quantifiable IBD scoring

•AI-based NHP Behavior Analysis System

FecalOccult — The DSS-induced IBD model demonstrates significant GI inflammation, weight loss, and altered stool characteristics, closely paralleling human disease.

key result and figure legend

The DSS-induced IBD model demonstrates significant GI inflammation, weight loss, and altered stool characteristics, closely paralleling human disease.

Colonoscopic images pre- and post-treatment, illustrating the reversal of mucosal damage.

Longitudinal changes in body weight and stool consistency during the study period.

Histopathological analysis of colon tissues, highlighting reductions in inflammatory markers post-therapy.

Hot Tags: inflammatory bowel disease ibd nhp model, research, study, monkey, gene therapy, preclinical contract, Coagulation Hemostasis Nonhuman Primates Disease Model, Embolism Nonhuman Primates Disease Model, Hemophilia A Nonhuman Primates Disease Model, NHP Lung Fibrosis, NHP pharmacodynamics pharmacology

Heart Failure NHP Model

Atopic Dermatitis NHP Model