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Aug 01, 2024Significance, Principles, And Requirements Of Safety Pharmacology ResearchThis article discusses the significance, principles, and requirements of safety pharmacology research in drug development. It highlights the importance of understanding a drug's... -
Aug 01, 2024How To Evaluate Preclinical Pharmacological Efficacy?Preclinical pharmacological efficacy evaluation plays a pivotal role in drug development. It encompasses understanding the mechanism of action, assessing potency, dose-response ...
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Aug 01, 2024Reflections On Non-clinical Pharmacology Studies And Evaluation Of Therapeuti...Non-alcoholic steatohepatitis (NASH) is characterized by a complex pathogenesis and pathological manifestations, and there is no animal model that fully reflects the clinical pa...
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Aug 01, 2024Advancing CNS And CGT Research: Prisys BiotechnologiesIn the rapidly evolving fields of Central Nervous System (CNS) and Cell and Gene Therapy (CGT) research, Prisys Biotechnologies pioneers breakthroughs. Leveraging preclinical ph...
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Aug 01, 2024Non-Human Primate Cerebrospinal Fluid Collection GuidelinesCerebrospinal fluid (CSF) analysis is a valuable tool for detecting various central nervous system processes in non-human primates, aiding in the diagnosis of conditions such as...
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Aug 01, 2024Considerations For Interpreting Clinical Pathology Data in Non-Human Primates...Interpreting clinical pathology data in preclinical studies involving non-human primates (NHPs) and canines is essential for maximizing research insights while minimizing animal...
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Aug 01, 2024Integrating CNS Safety Evaluation Into General Toxicology StudiesThe approach allows for the assessment of CNS function impacts due to repeated dosing, such as delayed effects, persistence, and intensity changes, as well as the reversibility ... -
Aug 01, 2024How To Conduct Preclinical Pharmacology/Toxicology Evaluation Of ADCs?Currently, there are numerous in vitro and in vivo non-clinical research methods, as well as the experience from the development of marketed drugs. However, predicting clinical ...
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Aug 01, 2024ADME Insights For Oligonucleotide Drugs (1) - Absorption, DistributionThe Oligonucleotide Safety Working Group (OSWG), represented by pharmaceutical companies like AstraZeneca, Novo Nordisk, Cardior Pharmaceuticals, and Alnylam Pharmaceuticals, h...
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Aug 01, 2024ADME Insights For Oligonucleotide Drugs (2) - Metabolism And ExcretionIn the previous article, we discussed the Absorption and Distribution of oligonucleotides (ONs) . In this article, we will continue the discussion by focusing on the Metabolism ...
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Aug 01, 2024Preclinical Animal Studies (1) - Animal SpeciesThe development of new drugs can be divided into four main stages: (1) Drug Discovery, (2) Preclinical Studies, (3) Clinical Studies, and (4) New Drug Application (NDA). During ...
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Aug 01, 2024Clinical Pathology Data Interpretation Challenges And Strategies in Preclinic...In the field of preclinical research, canines and non-human primates, such as beagle dogs and macaque monkeys, serve as vital experimental models. However, interpreting clinical...
