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Aug 01, 2024LCMS Preclinical Bioanalysis Of LNP-based Gene Therapy DrugsThe LCMS bioanalysis of LNP lipids focuses on cationic/ionizable lipids and PEG lipids. Due to the structural differences between them, cationic/ionizable lipid molecular weight... -
Aug 01, 2024The Role Of AAV in Gene Therapy: Immune Responses And ToxicityAdeno-Associated Virus (AAV) has emerged as a promising vector for gene therapy, demonstrating significant progress in treating genetic disorders such as hemophilia and Leber co... -
Aug 01, 2024Optimized Nonclinical Immunogenicity Evaluation StrategiesImmunogenicity assays are essential in clinical drug development, particularly for biotherapeutic products. Despite the regulatory focus on clinical requirements, nonclinical im... -
Aug 01, 2024Pharmacodynamic (PD) Evaluation Of Gene TherapyThe PD evaluation of gene therapy products usually involves the following aspects:Product protein expression level,Product protein activity and Biomarkers.which requires novel a... -
Aug 01, 2024Pharmacokinetics And Bioanalysis Of Oligonucleotide Drugs-(1)Oligonucleotide drugs, due to their unique chemical structure, exhibit suboptimal drug-like properties. They have a larger molecular weight, strong hydrophilicity, high negative... -
Aug 01, 2024Pharmacokinetics And Bioanalysis Of Oligonucleotide Drugs: Absorption And Pla...Oligonucleotide drugs exhibit limited oral absorption and are primarily administered through non-enteral routes. They are typically delivered via subcutaneous or intravenous inj... -
Aug 01, 2024Factors To Consider For The Immunogenicity Of Oligonucleotide DrugsOligonucleotide drugs have been developed for more than 40 years since the first one was born in 1978. However, their development has been slower than other types of drugs due t... -
Aug 01, 2024MRNA: A Powerful And Versatile Tool For Fighting Diseases-Prisys-BiotechmRNA, or messenger RNA, is a type of molecule that carries genetic information from DNA to the protein-making machinery of the cell. By delivering mRNA into cells, we can instru... -
Aug 01, 2024Chinese Scientists Offers New Strategies To Reverse Core Symptoms Of Parkinso...AAV innovative drug R&D to treat CNS diseases -
Aug 01, 2024Prisys Biotechnology: Novel Lipid Nanoparticles For MRNA Delivery in PrimatesThis article introduces two studies that demonstrate approaches for optimizing LNPs for mRNA delivery in NHP models and evaluating their translational potential. -
Aug 01, 2024How Drugs Move And Change in Our Bodies: A Brief Introduction To Pharmacokine...A Brief Introduction to Pharmacokinetics
