Prisys Biotech recently installed a magnetic resonance-guided system for precise localization and drug delivery in the nervous systems of large animals. Through a series of successful experiments, the system has demonstrated its effectiveness in achieving precise localization and drug delivery in large animal models, specifically Cynomolgus macaques.
Targeting a nucleus deep in a primate brain is a geometric problem before it is a pharmacological one. The structure may be a few millimetres across, it sits behind cortex, bone and ventricle, and it shifts with every breath. Frameless stereotaxis gets a surgeon close; what closes the remaining distance is imaging acquired with the animal already positioned for surgery. That is the gap this system fills.
The integration of this system into Prisys Biotech's research infrastructure supports the development of disease models in the large animal nervous system and enables targeted drug delivery for preclinical research. The technology also facilitates the assessment of drug effects on the nervous system in large animal models, which keeps study outcomes more controlled and easier to interpret. For programs that depend on where a dose lands rather than only on how much is given, that distinction decides whether a result can be reproduced.
Sub-millimeter Precision Localization
The system uses magnetic resonance imaging to achieve precise localization of neural nuclei in the animal brain, with a puncture accuracy reaching the sub-millimeter level. At that scale a target can be identified and treated specifically, rather than by injecting a region and hoping the structure of interest is inside it. The margin around the target also becomes visible on the planning image, so the trajectory can be chosen to avoid vessels and ventricles on the way in.
Application Of Micro-pump Technology
Integrated with micro-pump technology, the system delivers extremely small drug doses, with a minimum dosage rate of 0.01 microliters per hour. Infusion at that rate matters for neurological work that depends on controlling dose and flow together. Tissue accepts a slow, steady infusate far more readily than a bolus pushed in over seconds, which is the same principle behind Convection-Enhanced Delivery (CED) Technology: a sustained pressure gradient carries the drug through extracellular space instead of letting it pool at the catheter tip.
Technology Translation And Preclinical Research
The implementation of the magnetic resonance-guided large animal nervous system precision localization and delivery system supports a more direct transition from preclinical research to clinical trials. It provides a platform for the direct administration of gene therapy, cell therapy and other novel therapeutic approaches, using targeting logic that clinical neurosurgery also applies.
Magnetic resonance-guided precision puncture for the large animal nervous system involves accurate target selection and path planning.
During the procedure, the actual localization point deviates by 0.4mm horizontally and 0.6mm in depth from the target, showcasing the system's capability for precise intraoperative localization.
Inside the MR scanning room, medication is administered to a Cynomolgus macaque's hippocampus using a micro-pump through a CED (Convection Enhanced Delivery) catheter. The dosage administered is 20 microliters.
By incorporating the magnetic resonance-guided large animal nervous system precision localization and delivery system, along with MR imaging and specialized hardware, Prisys Biotech has achieved sub-millimeter precision in both localization and drug delivery within large animal nervous systems. The same integration has widened how scalable and flexible the platform is, because trajectory planning, verification and infusion now happen as one procedure rather than three disconnected steps.
Minimally invasive surgical techniques and precise localization have minimized tissue damage, which shows up as improved delivery efficiency. For a program heading toward the clinic, this shortens the distance between a preclinical infusion and the procedure a neurosurgical team would perform in a patient.
Taken together, the system gives large animal studies something they previously borrowed from the clinic: image-verified targeting, controlled infusion, and a record of where the dose went. The platform sits within Prisys Biotech's Translational-Research-Center, alongside the Clinical Imaging resources used for planning and follow-up. Related work on MRI-Guided Drug Delivery For CNS Research follows the same approach.
Prisys Biotech cordially extends an invitation for you to utilize our magnetic resonance-guided large animal nervous system precision localization and delivery system. Together, we can move new drug programs forward and put the resulting data to work for patients.
For any inquiries please don't hesitate to contact us at bd@prisysbiotech.com.
About Prisys Biotech
Prisys Biotechnology Co., Ltd., located in Shanghai, is a high-tech enterprise specializing in preclinical and translational evaluation of new drugs and the development of drug research technologies. The company is recognized as a "Shanghai Specialized and Innovative SME" and has obtained full AAALAC accreditation.
Prisys Biotech focuses on large animal pharmacology and pharmacodynamic research. The company provides services including disease model development, pharmacological and pharmacodynamic studies, safety evaluation, biomarker research, and mechanism-of-action studies. These services primarily utilize non-human primates (NHPs), experimental dogs, and other relevant animal species. Disease models cover multiple therapeutic areas, including the nervous, cardiovascular, metabolic, and renal systems.
Prisys Biotech has established a translational research center designed to support pharmaceutical and biotechnology research. The facility integrates NHP model development, translational research capabilities, standardized preclinical research, and Animal-Welfare practices.
