Prisys Biotech recently installed a magnetic resonance-guided system for precise localization and drug delivery in the nervous systems of large animals. Through a series of successful experiments, the system has demonstrated its effectiveness in achieving precise localization and drug delivery in large animal models, specifically Cynomolgus macaques.
The integration of this cutting-edge system into Prisys Biotech's infrastructure will significantly enhance the development of high-quality disease models in the large animal nervous system, enabling customers to perform targeted drug delivery with greater efficiency. Moreover, this advanced technology allows for more accurate assessment of the impact of new drugs on the nervous systems of large animals, leading to improved research outcomes.
By utilizing this system, you can streamline their research and development processes, saving both time and resources. The ability to perform precise localization and targeted drug delivery in the large animal nervous system not only expedites the study of potential therapeutics but also provides valuable competitive advantages in the biotech industry.
- Sub-millimeter precision localization: The system utilizes magnetic resonance imaging technology to achieve precise localization of neural nuclei in animal brains, with a puncture accuracy reaching the sub-millimeter level. This high level of precision allows for the accurate identification and treatment of specific neurological areas.
- Application of micro-pump technology: Integrated with micro-pump technology, the system enables the delivery of extremely small drug doses, with a minimum dosage rate of 0.01 microliters per hour. This capability is crucial for neurological research that requires precise control over drug dosages.
- Technology translation and preclinical research: The implementation of the magnetic resonance-guided large animal nervous system precision localization and delivery system ensures seamless transition from preclinical research to clinical trials. It provides an optimized platform for the direct administration of gene therapy, cell therapy, and other novel therapeutic approaches.
Magnetic resonance-guided precision puncture for the large animal nervous system involves accurate target selection and path planning.
During the procedure, the actual localization point deviates by 0.4mm horizontally and 0.6mm in depth from the target, showcasing the system's capability for precise intraoperative localization.
Inside the MR scanning room, medication is administered to a Cynomolgus macaque's hippocampus using a micro-pump through a CED (Convection Enhanced Delivery) catheter. The dosage administered is 20 microliters.
By incorporating the magnetic resonance-guided large animal nervous system precision localization and delivery system, along with MR imaging and specialized hardware, Prisys Biotech has successfully achieved sub-millimeter precision in both localization and drug delivery within large animal nervous systems. This integration has significantly enhanced the scalability and flexibility of the localization and drug delivery system.
The utilization of minimally invasive surgical techniques and precise localization has minimized tissue damage, resulting in improved delivery efficiency. This advancement in technology has expedited the process of high clinical translation, facilitating a seamless transition from preclinical research to clinical trials.
Overall, the introduction of the magnetic resonance-guided large animal nervous system precision localization and delivery system at Prisys Biotech has revolutionized the field, allowing for enhanced precision, efficiency, and clinical applicability in large animal studies.
Prisys Biotech cordially extends an invitation for you to utilize our magnetic resonance-guided large animal nervous system precision localization and delivery system. Together, we can propel innovation and achieve breakthroughs in the realm of new drug development, ultimately making a substantial contribution to the health and well-being of humanity.
For any inquiries please don't hesitate to contact us at bd@prisysbiotech.com.
About Prisys Biotech:
Prisys Biotechnology Co., Ltd., located in Shanghai, is a reputable high-tech enterprise specializing in the preclinical and quasi-clinical evaluation of new drugs and the development of innovative drug technologies. It holds the esteemed distinction of being recognized as a "Shanghai Specialized and New Small and Medium Enterprise" and has obtained full AAALAC accreditation.
Prisys Biotech is dedicated to emerging as a frontrunner in large animal pharmacological and pharmacodynamic research. The company offers a range of services, including disease model development, pharmacological and pharmacodynamic research, safety evaluation, biomarker research, and validation of mechanistic concepts. These services are primarily based on non-human primates (NHPs), experimental dogs, and other relevant animal species. Disease models encompass various fields, including the nervous system, cardiovascular system, metabolic system, and renal system.
Prisys Biotech established a translational medical center that adheres to pharmaceutical industry standards. This state-of-the-art facility integrates NHP model development, clinical-level research activities, industrial-scale research capabilities, and exemplary animal welfare practices.
