Cynomolgus monkeys are widely used in biomedical research because of their close genetic and physiological similarity to humans. Liver biopsy is an important tool for studying liver diseases, evaluating therapeutic responses, and supporting translational research. Compared with traditional surgical or blind biopsy methods, ultrasound-guided liver biopsy provides a minimally invasive approach for collecting high-quality liver tissue from living animals.
Using real-time ultrasound imaging, researchers can accurately guide the biopsy needle while avoiding major blood vessels and surrounding structures, improving sampling success and reducing the risks of bleeding, infection, and tissue injury. The technique also enables repeated sampling from the same animal, allowing longitudinal monitoring of disease progression and treatment response while supporting histological, molecular, and biomarker analyses.
Ultrasound-guided liver biopsy improves both research quality and animal welfare by enabling precise, reproducible tissue collection with minimal invasiveness. As an important technique in non-human primate research, it supports the development of reliable liver disease models and generates robust preclinical data for the evaluation of novel therapeutics.
