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May 20, 2024Prisys Biotech 2024 Q2 Newsletter - Enhanced Preclinical R&D For CNS Therapeu...Trans-BBB Delivery Platform: MRI-guided precision for targeted brain delivery. 3D-AI NHP BehaviorAtlasTM - 2nd Generation: Advanced gait analysis for ataxia and neuromuscular d... -
Aug 20, 2024Cynomolgus Monkey Chronic Kidney Disease (CKD) Model Of Prisys BiotechExplore Prisys Biotech's cynomolgus monkey CKD-UUO model, designed for accurate simulation of human renal fibrosis. Ideal for preclinical evaluation of anti-fibrotic therapies. ... -
Aug 01, 2024Nonclinical Safety Evaluation Of Ocular Drug Delivery Using Cynomolgus MacaquesOcular drug delivery is an innovative approach for treating retinal diseases, offering direct administration methods like intravitreal injections. This article provides an overv... -
Aug 12, 2024Understanding Compartment And Non-Compartment Models in PharmacokineticsExplore the fundamentals of pharmacokinetics, focusing on compartment and non-compartment models. Learn how these models help in drug development and dosing strategies, ensuring... -
Aug 09, 2024Advanced CNS Delivery Techniques in Cynomolgus Monkeys: Accelerating Oligonuc...Explore advanced CNS drug delivery techniques in cynomolgus monkeys at Prisys Biotech, focusing on intrathecal administration to accelerate oligonucleotide therapeutic developme... -
Aug 01, 2024Reducing The Use Of Nonhuman Primates in Nonclinical Safety Assessments: Pers...The COVID-19 pandemic has spurred rapid development of vaccines, leading to a surge in demand for nonhuman primates (NHPs) . Considering the "3R" principles (Replaceme... -
Aug 01, 2024LCMS Preclinical Bioanalysis Of LNP-based Gene Therapy DrugsThe LCMS bioanalysis of LNP lipids focuses on cationic/ionizable lipids and PEG lipids. Due to the structural differences between them, cationic/ionizable lipid molecular weight... -
Aug 01, 2024MRNA-based Therapies: Pastexplores the history, development, and applications of mRNA-based therapies. It delves into the mechanisms of mRNA technology, highlighting its advantages in treating various di... -
Aug 01, 2024Pharmacokinetic Study Strategies Of Peptide-Drug Conjugates (PDCs)Explore the innovative development and pharmacokinetic study strategies of Peptide-Drug Conjugates (PDCs). Learn about their advantages, payload forms, metabolism, and potential... -
Aug 01, 2024The Role Of AAV in Gene Therapy: Immune Responses And ToxicityAdeno-Associated Virus (AAV) has emerged as a promising vector for gene therapy, demonstrating significant progress in treating genetic disorders such as hemophilia and Leber co... -
Aug 01, 2024Optimized Nonclinical Immunogenicity Evaluation StrategiesImmunogenicity assays are essential in clinical drug development, particularly for biotherapeutic products. Despite the regulatory focus on clinical requirements, nonclinical im... -
Aug 01, 2024Pharmacodynamic (PD) Evaluation Of Gene TherapyThe PD evaluation of gene therapy products usually involves the following aspects:Product protein expression level,Product protein activity and Biomarkers.which requires novel a...
