Background：Intrahepatic cholangiocarcinoma is a cancer that develops in the cells within the bile ducts; both inside and outside the liver. Signs and symptoms of intrahepatic cholangiocarcinoma include jaundice, abdominal pain, fever, weight loss, weakness and itching. Treatment options may include surgery to remove the bile duct and parts of the liver, chemotherapy and radiation.

Model: Nitrate induced intrahepatic carcinoma (direct hepatic delivery)

Standard study duration: 12 months

Clinical endpoint: ultrasound, liver panel, liver biospy, urine and stool, oncology biomarkers

Features: mimic the oncogenesis procedures induced by common and known high-class carcinogen