Background: Pulmonary fibrosis is a chronic and progressive fibrotic interstitial pneumonia. It develops with the inflammation and fibrotic damage of alveoli, leading to the insufficient transfer of oxygen to blood.

Model: Bleomycin induced pulmonary fibrosis.

Standard study duration: 12 weeks.

Clinical endpoint: Bronchoalveolar Lavage Fluid (BALF), lung biopsy, CT, pulmonary function tests…

Features: Single lung lobe induction, self-comparison and control, dose-dependent disease severity, aerosol treatment…