Lung Fibrosis
Background: Pulmonary
fibrosis is a chronic and progressive fibrotic interstitial pneumonia. It
develops with the inflammation and fibrotic damage of alveoli, leading to the
insufficient transfer of oxygen to blood.
Model: Bleomycin induced pulmonary fibrosis.
Standard study duration: 12 weeks.
Clinical endpoint: Bronchoalveolar Lavage Fluid (BALF), lung
biopsy, CT, pulmonary function tests…
Features: Single
lung lobe induction, self-comparison and control, dose-dependent disease
severity, aerosol treatment…