Background: DTH is the type of hypersensitivity exemplified by such as the tuberculin reaction, which (as opposed to immediate hypersensitivity) takes 12 to 48 hours to develop following a challenge. DTH can be transferred by lymphocytes but not by serum.

Model: Tetanus toxin induced delayed-type hypersensitivity (DTH)

Standard study duration: 10 weeks.

Clinical endpoint: Skin induration, Biopsy, IHC….

Features: Repeated tests, self-control, cross-over tests, non-terminal, safety assessment…