Background：NASH is a progressive liver disorder that occurs in patients without significant alcohol consumption, and, histologically, it resembles the alcoholic liver disease with macrovesicular steatosis, spotty necrosis, inflammation, and fibrosis. The “two-hit theory” provides the mostly acceptable explanation for the progression of NASH. 
Model: Liver metabolic disorder combined with inflammation, oxidative stress or hepatotoxin induced NASH
Standard study duration: 24 weeks
Clinical endpoints: Liver function index, B-ultrasound, liver biopsy, NASH clinical scoring…
Features: Same human clinical symptoms and metabolic disorders, secondary diseases, gradually disease development…

Background: NAFLD is a type of fatty liver disease that is not related to heavy alcohol use. Simple fatty liver is when the fat accumulates in the liver with little or no inflammation or liver cell damage. It affects many people, but typically does not get bad enough to cause liver severe damage or complications. 

Model: High-fat Diet (HFD) induced NAFLD

Standard study duration: 24 weeks

Clinical endpoint: liver function index, triglyceride, B-ultrasound, Liver biopsy…

Features: Human-similar metabolic changes from diet components, gradually disease development, non-invasive procedures, and non-terminal studies…

For more information about these models, please contact Mr. James Song, mailto:james.song@prisysbiotech.com