Joint Efforts in the Development of a Novel Assay Modeling Middel Cerebral Artery Occlusion (MCAO) in Nonhuman Primate (NHP)


Cerebral infarction is an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain. The restricted oxygen due to the restricted blood supply causes an ischemic stroke that can result in an infarction if the blood flow is not restored within a relatively short period of time. The blockage can be due to a thrombus, an embolus or an atheromatous stenosis of one or more arteries.

Yet MCAO has been a major cerebrovascular disease in clinical practice which contributes to over 70% of all strokes overall. Once attack it normally requires emergency handling and expect to leave transient or permanent sequel. There has been several methods reported previously, in rodent or larger animals, successfully established MCAO, but often associated with severe complications or the procedure itself is too severe to pass the animal welfare audits. 

Together with Cerebrovascular scientists and physicians from a top hospital in Shanghai (Pudong General hospital), we here propose a new and less invasive method, using Digital subtraction angiography (DSA) and clinical vascular embolisation particles, to specifically occlude/reperfuse the M2-M3 in the MCA of NHPs. The occlusion and brain sequel will be quantitatively assessed with clinical endpoints and behavioral analysis.

The study will be initiated in mid-2020.

For more information about this model, please contact James Song